Influence of heritability on craniofacial soft tissue characteristics of monozygotic twins, dizygotic twins, and their siblings using Falconer’s method and principal components analysis
송정민, 채화성, 신정원, 성주헌, 송윤미, 백승학, 김영호,
소속 상세정보
송정민 ( Song Jeong-Min ) - Ajou University School of Medicine Department of Orthodontics
채화성 ( Chae Hwa-Sung ) - Ajou University School of Medicine Department of Orthodontics
신정원 ( Shin Jeong-Won ) - Ajou University School of Medicine Department of Orthodontics
성주헌 ( Sung Joo-Hon ) - Seoul National University School of Public Health Department of Epidemiology
송윤미 ( Song Yun-Mi ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Family Medicine
백승학 ( Baek Seung-Hak ) - Seoul National University School of Dentistry Department of Orthodontics
김영호 ( Kim Young-Ho ) - Ajou University School of Medicine Department of Orthodontics
Abstract
Objective: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings (SIB).
Methods: The samples comprised Korean adult twins and their siblings (mean age, 39.8 years; MZ group, n = 36 pairs; DZ group, n = 13 pairs of the same gender; and SIB group, n = 26 pairs of the same gender). Thirty cephalometric variables were measured to characterize facial profile, facial height, soft-tissue thickness, and projection of nose and lip. Falconer's method was used to calculate heritability (low heritability, h2 < 0.2; high heritability, h2 > 0.9). After principal components analysis (PCA) was performed to extract the models, we calculated the intraclass correlation coefficient (ICC) value and heritability of each component.
Results: The MZ group exhibited higher ICC values for all cephalometric variables than DZ and SIB groups. Among cephalometric variables, the highest h2(MZ-DZ) and h2(MZ-SIB) values were observed for the nasolabial angle (NLA, 1.544 and 2.036), chin angle (1.342 and 1.112), soft tissue chin thickness (2.872 and 1.226), and upper lip thickness ratio (1.592 and 1.026). PCA derived eight components with 84.5% of a cumulative explanation. The components that exhibited higher values of h2(MZ-DZ) and h2(MZ-SIB) were PCA2, which includes facial convexity, NLA, and nose projection (1.026 and 0.972), and PCA7, which includes chin angle and soft tissue chin thickness (2.107 and 1.169).
Conclusions: The nose and soft tissue chin were more influenced by genetic factors than other soft tissues.
키워드
Twin study; Craniofacial soft tissue characteristics; Cephalometric analysis; Heritability
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